Reaction #2273

Reaction equation

3-cyano-5-(4-chlorophenyl)-2-pyridinone

→

5-(4-chlorophenyl)-2-pyridinone

Yield 75.6%

Solvents

H3PO4

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureat reflux for 16 hours
3. 3
   Filtrationfiltered

Procedure

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

Source