Reaction #2267067

Reaction equation

3-methoxyphenylacetone

NaBH4

→

desired product 2

Yield 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

Yield 100.0%

Solvents

methanol

Conditions

Workup

1. 1
   ExtractionIt was extracted with CHCl3 three times
2. 2
   WashThe combined organic phase was washed with brine
3. 3
   Dryingdried over Na2SO4
4. 4
   OtherRemoval of the solvent
5. 5
   Otherafforded the crude product
6. 6
   OtherPurification of the crude product

Procedure

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

Source