Reaction #2226

Reaction equation

3-(4-chlorobenzoyl)-propionic acid

methyl hydrazine

→

product

6-(4-chlorophenyl)-2-methyl-4,5-dihydropyridazinone

Solvents

ethanol

Conditions

Workup

1. 1
   OtherTo a 250 ml flask equipped with magnetic stirrer
2. 2
   Temperaturereflux condenser
3. 3
   TemperatureThe reaction was refluxed for 3 hours
4. 4
   Temperaturecooled
5. 5
   Otherto yield a solid which
6. 6
   Filtrationwas collected by vacuum filtration
7. 7
   Washwashed with 50 ml of hexane, and air
8. 8
   Otherdried

Procedure

To a 250 ml flask equipped with magnetic stirrer and reflux condenser was charged 10 g of 3-(4-chlorobenzoyl)-propionic acid, 250 ml of absolute ethanol, and 2.5 ml of methyl hydrazine. The reaction was refluxed for 3 hours and cooled to yield a solid which was collected by vacuum filtration, washed with 50 ml of hexane, and air dried. Isolated 9.5 g of product as a white solid.

Source