Reaction #2200590
ord-7a3e402a4a8b4604936da49f3e7c46ea
Reaction equation
indolepyruvic acid
pyruvic acid
oxalacetic acid
→
4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid
Reagents
None
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Procedure
According to the study by the present inventors, it has been found that PtALD can catalyze the aldol condensation reaction of indolepyruvic acid with pyruvic acid (or oxalacetic acid) to yield 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid (IHOG), and the reaction of phenylpyruvic acid with pyruvic acid to yield 4-phenylmethyl-4-hydroxy-2-oxoglutaric acid (PHOG).