Reaction #2186191

Reaction equation

4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde

benzothiazol-2-yl-acetic acid methyl ester

piperidine

→

desired product

Yield 55.0%

3-Benzothiazol-2-yl-7-[4-(2-fluoro-ethyl)-piperazin-1-yl]-chromen-2-one

Yield 55.0%

Solvents

benzene

acetonitrile

Conditions

Workup

1. 1
   Otherto reach room temperature
2. 2
   Filtrationthe precipitate filtered off
3. 3
   Washwashed with diethylether
4. 4
   Otherdried under high vacuum

Procedure

200 mg (0.793 mmol) 4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde and 164 mg (1 eq.) benzothiazol-2-yl-acetic acid methyl ester are heated to reflux for 3 h in 5 mL benzene and 2.5 mL acetonitrile, in the presence of 0.157 mL (2 eq.) piperidine. The reaction mixture is allowed to reach room temperature and the precipitate filtered off, washed with diethylether and dried under high vacuum to yield 90 mg (55%) of desired product as a yellow powder (melting point: 246° C.).

Source