Reaction #2179431

Reaction equation

compound

2-(4-Chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylic acid

trimethylsilyl-diazomethane

→

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

Solvents

toluene

hexane

methanol

Conditions

Workup

1. 1
   Otherthe solvent is then removed on a rotary evaporator
2. 2
   OtherThe residue is used without further purification in the subsequent reaction

Procedure

138 mg (0.52 mmol) of the compound from Example 42A are dissolved in 3 ml toluene and 2.5 ml of methanol. 0.4 ml (0.79 mmol) of a 2 M solution of trimethylsilyl-diazomethane in hexane is then added dropwise. The mixture is stirred at RT for 10 min and the solvent is then removed on a rotary evaporator. The residue is used without further purification in the subsequent reaction.

Source