Reaction #2171040

Reaction equation

thiophosgene

imidazole

4-(4′-n-propylbicyclohexyl-4-yl)-2,6-difluorophenylamine

→

4′-(3,5-difluoro-4-isothiocyanatophenyl)-4-n-propylbicyclohexyl

Solvents

dichloromethane

Conditions

Workup

1. 1
   workup.STIRRINGthe mixture is stirred at RT for 24 hours

Procedure

4.9 ml of thiophosgene are added dropwise over the course of 30 minutes at 15-25° C. to 18.4 g of imidazole in 150 ml of dichloromethane, and the mixture is stirred at RT for a further 2 hours. 15.8 g of 4-(4′-n-propylbicyclohexyl-4-yl)-2,6-difluorophenylamine (prepared as described in Examples 1a-1e) are subsequently added, and the mixture is stirred at RT for 24 hours. Conventional work-up gives 4′-(3,5-difluoro-4-isothiocyanatophenyl)-4-n-propylbicyclohexyl having the following properties: C 65 N 225.5 1; Δε 16.0; Δn 0.1990.

Source