Reaction #2161261

Reaction equation

2,4,6-trichloropyrimidine

diethylamine

triethylamine

→

(2,6-Dichloro-pyrimidin-4-yl)-diethyl-amine

Solvents

ethanol

ethanol

Conditions

Workup

1. 1
   ConcentrationThe mixture was then concentrated
2. 2
   workup.ADDITION25 mL of CH2Cl2 and 25 mL of water were added
3. 3
   OtherThe organic layer was separated
4. 4
   Extractionthe aqueous layer was extracted by additional amount of dichloromethane (2×10 mL)
5. 5
   Dryingdried over anhydrous Na2SO4
6. 6
   Concentrationconcentrated
7. 7
   OtherColumn chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid

Procedure

To a stirred solution of 2.0 g (10.90 mmols) of 2,4,6-trichloropyrimidine in 25 mL of anhydrous ethanol at 0° C., was added drop wise a solution 0.79 g (10.90 mmols) of diethylamine in 5 mL of ethanol. This was followed by the addition of 2.3 mL (16.35 mmols) of triethylamine and the mixture was stirred for further 30 min. The mixture was then concentrated and 25 mL of CH2Cl2 and 25 mL of water were added. The organic layer was separated and the aqueous layer was extracted by additional amount of dichloromethane (2×10 mL) and the extracts were combined, dried over anhydrous Na2SO4 and concentrated. Column chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid.

Source