Reaction #2161254

Reaction equation

ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

Solvents

ethanol

Conditions

Workup

1. 1
   FiltrationThe reaction solution is then filtered through kieselguhr
2. 2
   Concentrationthe filtrate is concentrated
3. 3
   OtherThe residue is dried in vacuo
4. 4
   Otherreacted further without further purification

Procedure

0.50 g (2.5 mmol) of ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate are dissolved in 7.5 ml of ethanol, 0.13 g (0.13 mmol) of palladium-on-carbon (10%) are added and the mixture is hydrogenated at 3 bar for 12 h. The reaction solution is then filtered through kieselguhr and the filtrate is concentrated. The residue is dried in vacuo and reacted further without further purification.

Source