Reaction #2161251

Reaction equation

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Solvents

THF

Conditions

Workup

1. 1
   FiltrationThe catalyst is filtered off
2. 2
   Concentrationthe filtrate is concentrated in vacuo
3. 3
   OtherThe concentration residue is directly used further for the next reaction

Procedure

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

Source