Reaction #215703

Reaction equation

ethyl (2-bromo-3,4,5,6-tetrafluorobenzoyl)-acetate

acetic anhydride

triethyl orthoformate

→

Ethyl 2-(2-bromo-3,4,5,6-tetrafluoro-benzoyl)-3-ethoxyacrylate

Conditions

Workup

1. 1
   Temperaturethe mixture is heated
2. 2
   Temperatureunder reflux for 2 hours

Procedure

45 g of crude ethyl (2-bromo-3,4,5,6-tetrafluorobenzoyl)-acetate are introduced into 32.2 g (0.31 mol) of acetic anhydride and 28.4 g (0.19 mol) of triethyl orthoformate and the mixture is heated under reflux for 2 hours. Excess reagent is stripped off, first in vacuo and then under a high vacuum (bath up to 120°-130° C.), and the crude product is reacted for the next stage.

Source