Reaction #215

Reaction equation

CC(Nc1nc(Cl)nc(N2CCO

Cc1cc(N)nn1C(=O)OC(C

→

Cc1cc(Nc2nc(NC(C)c3n

Solvents

C1COCCO1

Conditions

Procedure

9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (27.9 mg, 0.05 mmol), 2-chloro-N-(1-(3,5-difluoropyridin-2-yl)ethyl)-5-fluoro-6-morpholinopyrimidin-4-amine (200 mg, 0.54 mmol), tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate (127 mg, 0.64 mmol) and cesium carbonate (349 mg, 1.07 mmol) were added to dioxane (8 mL). The mixture was purged with nitrogen for 15 minutes. Pd2(dba)3 (29.4 mg, 0.03 mmol) was added and the mixture heated at 110 °C for 3h. No sign of any reaction.

Source