Reaction #214909

ord-33a23f1db82a44a883dbaabee6730d1b

Reaction equation

Cc1ccc(S(=O)(=O)O)cc1.O=C1COCC(=O)N1CCCCCCN1CCCCC1
4-(6-piperidinohexyl)-3,5-dioxomorpholine p-toluenesulfonate
Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonate
[Na+].[OH-]
sodium hydroxide
O=C1COCC(=O)N1CCCCCCN1CCCCC1
4-(6-piperidinohexyl)-3,5-dioxomorpholine
→
O=C([O-])COCC(=O)NCCCCCCN1CCCCC1.[Na+]
sodium [2-(6-piperidinohexyl)amino-2-oxoethoxy]acetate
Cc1ccc(S(=O)(=O)[O-])cc1.[Na+]
sodium tosylate

Reactants

Cc1ccc(S(=O)(=O)O)cc1.O=C1COCC(=O)N1CCCCCCN1CCCCC1
4-(6-piperidinohexyl)-3,5-dioxomorpholine p-toluenesulfonate
Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonate
[Na+].[OH-]
sodium hydroxide
O=C1COCC(=O)N1CCCCCCN1CCCCC1
4-(6-piperidinohexyl)-3,5-dioxomorpholine

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Preparation in situ from 4-(6-piperidinohexyl)-3,5-dioxomorpholine-p-toluenesulfonate. 43 milligrams (0.095 millimole) of 4-(6-piperidinohexyl)-3,5-dioxomorpholine.p-toluenesulfonate (prepared as described in Example IX) was dissolved in 2 milliliters of 0.1 N sodium hydroxide (0.2 millimole) to obtain an aqueous solution of sodium [2-(6-piperidinohexyl)amino-2-oxoethoxy]acetate and sodium tosylate. The solution had the following spectral characteristics:

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04256891uspto-grants-1981_03