Reaction #214901

Reaction equation

1-phenylsemicarbazide

β,β-dichloroacryloyl chloride

→

1-(β,β-dichloroacryloyl)-1-phenyl-semicarbazide

Yield 63.0%

Solvents

acetonitrile

Conditions

Workup

1. 1
   Temperaturecooled down to 0°-5° C.
2. 2
   workup.ADDITIONThe addition
3. 3
   workup.STIRRINGthe reaction mixture was stirred at 5° C. for 30 minutes
4. 4
   Otherat room temperature
5. 5
   OtherThe solid that separated
6. 6
   Otherwas collected
7. 7
   Otherby decanting and by filtration
8. 8
   Washwas washed with diethylether

Procedure

To a suspension of 7 g of 1-phenylsemicarbazide in 100 ml of acetonitrile, cooled down to 0°-5° C., were added 7.4 g of β,β-dichloroacryloyl chloride, under stirring. The addition having been completed, the reaction mixture was stirred at 5° C. for 30 minutes and then at room temperature for 1 (one) hour. The solid that separated was collected by decanting and by filtration, then was washed with diethylether, thus obtaining 8 g of 1-(β,β-dichloroacryloyl)-1-phenyl-semicarbazide, in accordance with the elemental analysis and the I.R. and N.M.R. spectra.

Source