Reaction #2146768

Reaction equation

p-methoxybenzylchloride

6-fluoro-isoquinolinone

Cs2CO3

→

title compound

Yield 93.7%

6-Fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

Yield 93.7%

Solvents

DMF

Conditions

Workup

1. 1
   workup.ADDITIONpoured on ice
2. 2
   FiltrationThe precipitate was filtered
3. 3
   Washwashed with water
4. 4
   Otherdried

Procedure

169 μL of p-methoxybenzylchloride (1.24 mmol, 1.1 eq) were added to a suspension of 200 mg of 6-fluoro-isoquinolinone (13) (1.13 mmol) and 368 mg of Cs2CO3 (1.36 mmol, 1.2 eq) in 3 mL of DMF. The mixture was stirred for 2 h and then poured on ice. The precipitate was filtered, washed with water and dried to yield 300 mg of the title compound. LCMS Method B, retention time 1.76 min, detected mass 284.14 [M+H]+

Source