Reaction #2146764

Reaction equation

4-(1-Benzyloxy-7-chloro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl-ester

→

desired compound

Yield 69.6%

7-Chloro-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one-hydrochloride

Yield 69.6%

Solvents

methanol

Conditions

Workup

1. 1
   OtherThe solvent was removed i
2. 2
   Otherand the residue was purified by preparative HPLC
3. 3
   OtherThe product fractions were evaporated
4. 4
   workup.DISSOLUTIONdissolved in 2 N HCl

Procedure

254 mg (0.52 mmol) of 4-(1-Benzyloxy-7-chloro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl-ester (6) were stirred in methanol/2 N HCl (1:1) at room temperature overnight. The solvent was removed i. vac. and the residue was purified by preparative HPLC. The product fractions were evaporated and dissolved in 2 N HCl. Lyophilization results in 57 mg of the desired compound. Rt=0.95 min (Method B). Detected mass: 279.1 (M+H+).

Source