Reaction #2140

ord-c44c4a79058347d5a7012c9e47dfad0e

Reaction equation

Cn1c(=O)[nH]c(=O)c2[nH]cnc21.[Na].[Na]
3-methylxanthine disodium salt
CP(C)(=O)CCl
chloromethyldimethylphosphine oxide
→
Cn1c(=O)n(CP(C)(C)=O)c(=O)c2c1ncn2P(C)(C)=O
[1-(7-Dimethylphosphinyl-3-methylxanthin-1-yl)methyl]dimethylphosphine Oxide

Reactants

Cn1c(=O)[nH]c(=O)c2[nH]cnc21.[Na].[Na]
3-methylxanthine disodium salt
CP(C)(=O)CCl
chloromethyldimethylphosphine oxide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Othercrystallized from methanol

Procedure

The title substance was prepared from 22 g (0.1 mol) of 3-methylxanthine disodium salt and chloromethyldimethylphosphine oxide analogously to Example 59 and crystallized from methanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03