Reaction #2139951

Reaction equation

3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)-benzo[c]chromen-6-one

Lawesson's reagent

→

3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)benzo[c]chromene-6-thione

Yield 65.3%

Solvents

chlorobenzene

Conditions

Workup

1. 1
   FiltrationThe solution was subsequently filtered through silica gel
2. 2
   Otherevaporated
3. 3
   Otherthe crude product was purified by crystallisation from MTB ether

Procedure

11.7 g (25.6 mmol) of 3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)-benzo[c]chromen-6-one and 11.4 g (28.2 mmol) of Lawesson's reagent were refluxed for 16 hours in 130 ml of chlorobenzene. The solution was subsequently filtered through silica gel and evaporated, and the crude product was purified by crystallisation from MTB ether, giving 7.9 g (65%) of 3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)benzo[c]chromene-6-thione as yellow crystals.

Source