Reaction #2133

ord-465ca427a226420c828105b026a9c1d8

Reaction equation

CCOP(=O)(CCCn1c(=O)c2[nH]cnc2n(C)c1=O)OCC
diethyl [3-(3-methyl-xanthin-1-yl)propyl]phosphonate
ClCC1CC1
chloromethylcyclopropane
→
CCOP(=O)(CCCn1c(=O)c2c(ncn2CC2CC2)n(C)c1=O)OCC
Diethyl [3-(7-cyclopropylmethyl-3-methylxanthin-1-yl)propyl]phosphonate

Reactants

CCOP(=O)(CCCn1c(=O)c2[nH]cnc2n(C)c1=O)OCC
diethyl [3-(3-methyl-xanthin-1-yl)propyl]phosphonate
ClCC1CC1
chloromethylcyclopropane

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)

Procedure

The title substance was prepared from 0.015 mol of diethyl [3-(3-methyl-xanthin-1-yl)propyl]phosphonate (Example 42), and 0.017 mol of chloromethylcyclopropane analogously to Example 30 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03