Reaction #2132

ord-dbd5f59d9f5c45dc83584e93fb652d29

Reaction equation

Cn1c(=O)[nH]c(=O)c2c1ncn2Cc1ccccc1
7-benzyl-3-methylxanthine
CCOP(=O)(CCCCCBr)OCC
diethyl 5-bromopentanephosphonate
→
CCOP(=O)(CCCCCn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O)OCC
title compound
CCOP(=O)(CCCCCn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O)OCC
Diethyl [5-(7-benzyl-3-methylxanthin-1-yl)pentyl]phosphonate

Reactants

Cn1c(=O)[nH]c(=O)c2c1ncn2Cc1ccccc1
7-benzyl-3-methylxanthine
CCOP(=O)(CCCCCBr)OCC
diethyl 5-bromopentanephosphonate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared from 7-benzyl-3-methylxanthine (0.059 mol) and diethyl 5-bromopentanephosphonate (0.07 mol) analogously to Example 23.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03