Reaction #2129

ord-850bc9b85c9e4146b22bb952817275a6

Reaction equation

CCCCn1cnc2c1c(=O)[nH]c(=O)n2CCCC
3,7-dibutylxanthine
CCOP(=O)(CCCBr)OCC
diethyl 3-bromopropanephosphonate
→
CCCCn1cnc2c1c(=O)n(CCCP(=O)(OCC)OCC)c(=O)n2CCCC
Diethyl [3-(3,7-dibutylxanthin-1-yl)propyl]phosphonate

Reactants

CCCCn1cnc2c1c(=O)[nH]c(=O)n2CCCC
3,7-dibutylxanthine
CCOP(=O)(CCCBr)OCC
diethyl 3-bromopropanephosphonate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)

Procedure

The title substance was prepared from 0.02 mol of 3,7-dibutylxanthine and 0.022 mol of diethyl 3-bromopropanephosphonate analogously to Example 23 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03