Reaction #2125

Reaction equation

3-ethylxanthine

benzyl bromide

potassium carbonate

→

7-Benzyl-3-ethylxanthine

Solvents

water

Conditions

Workup

1. 1
   FiltrationThe precipitate was filtered off with suction
2. 2
   Washwashed several times with warm water
3. 3
   Otherdried at 50° C. under reduced pressure

Procedure

18 g (0.1 mol) of 3-ethylxanthine were stirred at 60° C. for 2 hours with 19.2 g (0.11 mol) of benzyl bromide and 15.2 g (0.11 mol) of potassium carbonate. The reaction solution was transferred to an Edenmeyer flask and treated with 1000 ml of water. The precipitate was filtered off with suction, washed several times with warm water and dried at 50° C. under reduced pressure.

Source