Reaction #2124

ord-26849af8cbc844578b2946656b10208a

Reaction equation

CCOCn1cnc2c1c(=O)[nH]c(=O)n2C
7-ethoxymethyl-3-methylxanthine
CCOP(=O)(CCCBr)OCC
diethyl 3-bromopropanephosphonate
→
CCOCn1cnc2c1c(=O)n(CCCP(=O)(OCC)OCC)c(=O)n2C
Diethyl [3-(7-ethoxymethyl-3-methylxanthin-1-yl)propyl]phosphonate

Reactants

CCOCn1cnc2c1c(=O)[nH]c(=O)n2C
7-ethoxymethyl-3-methylxanthine
CCOP(=O)(CCCBr)OCC
diethyl 3-bromopropanephosphonate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherchromatographed on silica gel (eluent: ethyl acetate/methanol 10:1)

Procedure

The title substance was prepared from 0.048 mol of 7-ethoxymethyl-3-methylxanthine and 0.058 mol of diethyl 3-bromopropanephosphonate analogously to Example 32 and chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728686uspto-grants-1998_03