Reaction #2122729

Reaction equation

6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester

→

title compound

Yield 100.0%

4-amino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid ethyl ester

Yield 100.0%

Solvents

methanol

potassium carbonate

water

water

Conditions

Workup

1. 1
   workup.ADDITIONwas added
2. 2
   Extractionextracted with ethyl acetate
3. 3
   Washthe extract was washed with saturated saline
4. 4
   Dryingdried on anhydrous sodium sulfate
5. 5
   OtherThe solvent was evaporated

Procedure

51 mg of 6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester was dissolved in 5 mL of methanol, to which 3 mL of 2 mol/L potassium carbonate in water was added, and stirred at room temperature for 4 hours. To the reaction mixture water was added, extracted with ethyl acetate, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 42 mg (yield 100%) of the title compound as a light yellow solid.

Source