Reaction #2116

Reaction equation

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

Solvents

ethanol

Conditions

Workup

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure
3. 3
   Otherthe solution obtained
4. 4
   Otherafter evaporating the solvent
5. 5
   Otherwas then crystallized from diisopropyl ether

Procedure

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

Source