Reaction #2103

Reaction equation

7-ethoxymethylxanthine

1,5-dibromopentane

potassium carbonate

→

1-(5-Bromopentyl)-7-ethoxymethyl-3-methylxanthine

Conditions

Workup

1. 1
   FiltrationThe solution was filtered
2. 2
   Concentrationconcentrated
3. 3
   Otherthe oily residue which remained was chromatographed (eluent: ethyl acetate)

Procedure

22.4 g (0.1 mol) of 7-ethoxymethylxanthine were stirred at 70° C. for 1.5 hours with 45.9 g (0.2 mol) of 1,5-dibromopentane and 27.6 g of activated potassium carbonate. The solution was filtered and concentrated, and the oily residue which remained was chromatographed (eluent: ethyl acetate).

Source