Reaction #2092

Reaction equation

7-benzyl-3-methylxanthine

ethoxymethyl chloride

potassium carbonate

→

7-Benzyl-1-ethoxymethyl-3-methylxanthine

Solvents

dimethylformamide

Conditions

Workup

1. 1
   Filtrationthe mixture was filtered
2. 2
   Concentrationconcentrated
3. 3
   Otherthe residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1)

Procedure

20 g (0.078 mol) of 7-benzyl-3-methylxanthine were stirred at 80° C. for 6 hours with 8.8 g (0.094 mol) of ethoxymethyl chloride and 13 g of potassium carbonate in 500 ml of absolute dimethylformamide, the mixture was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).

Source