Reaction #2084

Reaction equation

benzyl bromide

7-ethoxymethyl-3-methylxanthine

potassium carbonate

→

1-Benzyl-7-ethoxymethyl-3-methylxanthine

Solvents

dimethylformamide

Conditions

Workup

1. 1
   FiltrationThe reaction solution was filtered hot
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure
3. 3
   Otherthe residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

Procedure

205 g (1.2 mol) of benzyl bromide were added to a suspension of 224 g (1 mol) of 7-ethoxymethyl-3-methylxanthine and 165 g of potassium carbonate in 1000 ml of dimethylformamide and the mixture was then stirred overnight at 90° C. The reaction solution was filtered hot, the filtrate was concentrated under reduced pressure and the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

Source