Reaction #2075691

Reaction equation

2-aminopropan-1,3-diol

ethyl trifluoroacetate

→

2,2,2-trifluoro-N-(2-hydroxy-1-hydroxymethylethyl)acetamide

Solvents

tetrahydrofuran

Conditions

Procedure

4 g of 2-aminopropan-1,3-diol (43.9 mmol) were supplemented with 20 ml of tetrahydrofuran. The reaction mixture was then cooled to 0° C. on an ice bath and 5.8 ml of ethyl trifluoroacetate (48.3 mmol) were gradually added. This solution was stirred for 2 hours at room temperature.

Source