Reaction #2069978

Reaction equation

piperazine-1-carboxylic acid tert-butyl ester

phenyl isocyanate

→

title compound

4-Phenylcarbamoyl-piperazine-1-carboxylic acid tert-butyl ester

Solvents

DCM

Conditions

Workup

1. 1
   workup.WAITAfter 15 h
2. 2
   Filtrationthe resulting mixture was filtered
3. 3
   Washthe solid was washed with DCM (2×100 mL)

Procedure

A 0° C. solution of piperazine-1-carboxylic acid tert-butyl ester (114 g) in DCM (500 mL) was treated with phenyl isocyanate (65 mL). After 1 hour (h), the mixture was allowed to warm to room temperature (rt). After 15 h, the resulting mixture was filtered and the solid was washed with DCM (2×100 mL), giving the title compound as a white amorphous solid (95 g).

Source