Reaction #2069924

Reaction equation

Acetic anhydride

4-isopropylaniline

→

N-Acetyl-4-isopropylaniline

Solvents

chloroform

Conditions

Workup

1. 1
   TemperatureIn the course of this, intense heating of the reaction mixture
2. 2
   workup.ADDITIONOn completion of the dropwise addition
3. 3
   ConcentrationThe reaction mixture is concentrated to dryness
4. 4
   Otherthe resulting, reddish-white solid is recrystallized from hexane

Procedure

Acetic anhydride (26.0 g, 254 mmol) is slowly added dropwise to a solution of 4-isopropylaniline (17.2 g, 127 mmol) in 80 ml of chloroform. In the course of this, intense heating of the reaction mixture occurs. On completion of the dropwise addition, the mixture is stirred at room temperature for another 2 h. The reaction mixture is concentrated to dryness and the resulting, reddish-white solid is recrystallized from hexane.

Source