Reaction #2049627

Reaction equation

4-bromo-1-chloro-5-nitroisoquinoline

tetrahydrofuran

→

title compound

Yield 102.1%

5-Amino-1-chloro-4-bromoisoquinoline

Yield 102.1%

Solvents

ethanol

Conditions

Workup

1. 1
   Otherthe insoluble solids were removed by filtration through Celite
2. 2
   Otherthe solvent was evaporated under reduced pressure

Procedure

A solution of 4-bromo-1-chloro-5-nitroisoquinoline (14.0 g) prepared according to the method described in a known literature (Nair et al., Indian J. Chem., 1967, 5, 403) in ethanol (75 ml) and tetrahydrofuran (75 ml) was added with 3% platinum-sulfur/activated carbon (3% Pt—S/C, NE Chemcat, CM101, 14.0 g), and the mixture was stirred at room temperature for 15 hours under a hydrogen gas atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble solids were removed by filtration through Celite, and the solvent was evaporated under reduced pressure to obtain the title compound (12.8 g).

Source