Reaction #2045067

ord-fe0bcc1ac6b841a6b775509ee43b888b

Reaction equation

CC1=C(C=O)C(C)(C)CCC1
2,6,6-trimethylcyclohex-1-enecarbaldehyde
CC1CCCC(C)(C)C1CCCC(=O)O
4-(2,2,6-trimethylcyclohexyl)butanoic acid
CC1CCC(CCCC(=O)O)C1(C)C
4-(2,2,3-trimethylcyclopentyl)butanoic acid
→
CC1CCCC(C)(C)C1CCC(=O)O
3-(2,2,6-trimethylcyclohexyl)propanoic acid

Reactants

CC1=C(C=O)C(C)(C)CCC1
2,6,6-trimethylcyclohex-1-enecarbaldehyde
CC1CCCC(C)(C)C1CCCC(=O)O
4-(2,2,6-trimethylcyclohexyl)butanoic acid
CC1CCC(CCCC(=O)O)C1(C)C
4-(2,2,3-trimethylcyclopentyl)butanoic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

3-(2,2,6-trimethylcyclohexyl)propanoic acid was synthesized in three steps starting from 2,6,6-trimethylcyclohex-1-enecarbaldehyde, analogous to the 3-step procedure described for 4-(2,2,6-trimethylcyclohexyl)butanoic acid and 4-(2,2,3-trimethylcyclopentyl)butanoic acid herein-above, as indicated below.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08409649B2uspto-grants-2013_04