Reaction #2045039

Reaction equation

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

Yield 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Yield 80.2%

Solvents

HCl

Conditions

Workup

1. 1
   Temperaturewas refluxed for 16 hours
2. 2
   Filtrationfiltered
3. 3
   Otherdried
4. 4
   Otherrecrystallised from a mixture of ethyl acetate:hexane (1:6)

Procedure

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

Source