Reaction #2045007
ord-9aba51634b83439c8b305fedd0029c86
Reaction equation
2-(4-Acetylaminophenoxy)propionic acid methyl ester
2-(4-Acetylamino-phenoxy)-propionic acid methyl ester
→
17
Yield 98.1%
2-(4-Amino-phenoxy)-propionic acid
Yield 98.1%
Reactants
Reagents
None
Solvents
Conditions
Temperature
10°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Temperaturewas refluxed for 48 hours
- 2workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
- 3Filtrationfiltered hot
- 4Filtrationfiltered
- 5Otherdried
Procedure
A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.