Reaction #2028884

Reaction equation

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

Yield 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

Yield 85.1%

Solvents

ether

Conditions

Workup

1. 1
   OtherThe organic layer was collected
2. 2
   Washwashed with brine
3. 3
   Dryingdried over MgSO4
4. 4
   Concentrationconcentrated in vacuo

Procedure

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

Source