Reaction #2027389

Reaction equation

tetrahydrofuran

(3R,5S)-7-Chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid

aluminum lithium hydride

→

non-crystalline solid

Yield 88.2%

(3R,5S)-7-Chloro-5-(2-chlorophenyl)-3-(2-hydroxyethyl)-1-neopentyl-1,2,3,5-tetrahydro-4,1-benzoxazepine

Yield 88.2%

Solvents

water

Conditions

Workup

1. 1
   TemperatureThe mixture was heated for 6 hours
2. 2
   Temperatureunder reflux, to which
3. 3
   FiltrationInsolubles were then filtered off
4. 4
   ConcentrationThe filtrate was concentrated
5. 5
   Otherwhich was purified by means of a silica gel column chromatography (hexane

Procedure

To tetrahydrofuran (20 ml) were added (3R,5S)-7-Chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid (2 g) and aluminum lithium hydride (0.4 g). The mixture was heated for 6 hours under reflux, to which was added water. Insolubles were then filtered off. The filtrate was concentrated, which was purified by means of a silica gel column chromatography (hexane:acetic acid ethyl ester=2:1 v/v as an eluent) to give 1.65 g of non-crystalline solid matter.

Source