Reaction #2013587

ord-47fff94fb4114dbdb6ee759ab3e8b974

Reaction equation

Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2c(C(F)(F)F)cccc2s1
5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine
N#Cc1ccc2nc(Cl)sc2c1
2-chloro-1,3-benzothiazole-6-carbonitrile
→
N#Cc1ccc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)sc2c1
title compound
N#Cc1ccc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)sc2c1
2-[2-Amino-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-3-yl]-benzothiazole-6-carbonitrile

Reactants

Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2c(C(F)(F)F)cccc2s1
5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine
N#Cc1ccc2nc(Cl)sc2c1
2-chloro-1,3-benzothiazole-6-carbonitrile

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Following the procedure for 5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-3-(4-trifluoromethylbenzothiazol-2-yl)-pyridin-2-ylamine, but using 2-chloro-1,3-benzothiazole-6-carbonitrile, the title compound was obtained as yellow solid. MS (ES+): m/z=402.13 [MH+].

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08178668B2uspto-grants-2012_05