Reaction #2013565

Reaction equation

3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

2-iodo-4-methyl-1,3-benzothiazole

→

title compound

3-(4-Methylbenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Conditions

Procedure

Same procedure as 3-(6-fluorobenzothiazol-2-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine except using 2-iodo-4-methyl-1,3-benzothiazole in place of 2-chloro-6-fluorobenzothiazole to afford the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.10-2.31 (m, 4H), 2.74 (s, 3H), 3.05-3.18 (m, 2H), 3.41 (d, J=13.2 Hz, 2H), 4.49-4.57 (m, 1H), 7.41-7.48 (m, 2H), 8.02 (dd, J=6.4, 2.7 Hz, 1H), 8.09 (s, 1H), 8.45 (s, 1H), 8.49 (br. s., 1H), 8.56 (d, J=1.8 Hz, 1H). MS (ES+): m/z=391.14 [MH+]. HPLC: tR=2.11 min (ZQ2, polar—5 min).

Source