Reaction #2000960

Reaction equation

methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-en-1-yl]benzoate

potassium carbonate

1,1,1-trifluoro-5-bromopentane

→

title compound

Methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-{2-[(5,5,5-trifluoropentyl)oxy]phenyl}but-3-en-1-yl]benzoate

Solvents

acetonitrile

Conditions

Workup

1. 1
   Temperatureunder reflux for 12 h
2. 2
   Filtrationthe salts are filtered off
3. 3
   Otherthe mother liquor is evaporated

Procedure

A solution of 200 mg (0.486 mmol) of methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-en-1-yl]benzoate in 10 ml of acetonitrile is mixed with 101 mg (0.73 mmol) of potassium carbonate and 149 mg (0.73 mmol) of 1,1,1-trifluoro-5-bromopentane [CAS Reg. No. 54932-74-00] and stirred under reflux for 12 h. After conversion is complete, the salts are filtered off and the mother liquor is evaporated. 205 mg (0.28 mmol, 79% of theory) of the title compound are obtained.

Source