Reaction #1994240

ord-18f9c90d2443485eb7e9a4759defbe40

Reaction equation

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr
→
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
Dextromethorphan

Reactants

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr

Reagents

None

Solvents

O
water

Conditions

Temperature
77.5°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    workup.ADDITIONfollowed by the addition of 223.01 g AMBERLITE IRP-69 resin
  2. 2
    workup.ADDITIONunder gentle mixing for 4 hours
  3. 3
    Otherwas then decanted
  4. 4
    Washrinsed with purified water twice
  5. 5
    Otherdried in an oven
  6. 6
    Temperaturemaintained at 50° C. until the moisture content
  7. 7
    Filtrationsieved through a 40 mesh screen

Procedure

Uncoated Dextromethorphan Resin Complex was prepared by first dissolving 119.28 g of dextromethorphan HBr in 1 L of purified water heated to 75-80° C., followed by the addition of 223.01 g AMBERLITE IRP-69 resin under gentle mixing for 4 hours. At the completion, the suspension was allowed to settle, and was then decanted and rinsed with purified water twice and dried in an oven maintained at 50° C. until the moisture content was around 5%. The dried resin complex was hand sieved through a 40 mesh screen.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08597684B2uspto-grants-2013_12