Reaction #1994225

Reaction equation

HCl

Rotigotine HCl

Boc-Glycine-OH

DCC

→

Boc-Gly Rotigotine

Solvents

diethyl ether

dichloromethane

Conditions

Workup

1. 1
   Otherto give a suspension
2. 2
   FiltrationThe mixture was filtered
3. 3
   Filtrationusing filter paper
4. 4
   OtherThe layers were separated
5. 5
   Extractionthe aqueous phase was extracted with 7 mL of dichloromethane
6. 6
   WashThe combined organic phases were washed with water
7. 7
   Dryingwith brine, dried over Na2SO4
8. 8
   Filtrationfiltered
9. 9
   Concentrationconcentrated
10. 10
    Othera rotary evaporator
11. 11
    Otherdried in vacuo
12. 12
    Otherto give a crude pale yellow solid
13. 13
    Filtrationfiltered on a glass frit
14. 14
    Washwashed with diethyl ether
15. 15
    Otherdried in vacuo

Procedure

Rotigotine HCl (1.2 g, 3.41 mmol) and Boc-Glycine-OH (1.195 g, 6.82 mmol) were dissolved in dichloromethane (150 ml) to give a suspension. After addition of DMAP (0.625 g, 5.11 mmol) and DCC (1.407 g, 6.82 mmol), the mixture was stirred for 16 hours at room temperature. The mixture was filtered using filter paper and the filtrate was quenched with 51 mL of 0.1 N HCl (5.11 mmol). The layers were separated and the aqueous phase was extracted with 7 mL of dichloromethane. The combined organic phases were washed with water and then with brine, dried over Na2SO4, filtered, concentrated using a rotary evaporator, and dried in vacuo to give a crude pale yellow solid. The crude material was stirred with diethyl ether (50 mL) for 30 minutes, filtered on a glass frit, washed with diethyl ether, and dried in vacuo to give a pale yellow powder Boc-Gly-Rotigotine.HCl (1.258 g, 75% yield).

Source