Reaction #1973962

Reaction equation

product

methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate

toluene

acrylic acid

acrylic acid

→

crude title compound

3-(3-tert-butyl-4-methoxy-5-(methoxycarbonyl)phenylamino) propanoic acid

Conditions

Workup

1. 1
   TemperatureThis mixture was heated
2. 2
   Temperatureto reflux
3. 3
   workup.ADDITIONadded every 3 h
4. 4
   TemperatureThe mixture was then refluxed for 24 h
5. 5
   TemperatureThe mixture was then cooled
6. 6
   Concentrationconcentrated under vacuum to dryness

Procedure

The product from Example 5, Part C (16.44 g, 69.3 mmol) was dissolved in toluene (200 mL). This mixture was heated to reflux and acrylic acid added over time (1 mL of acrylic acid added every 3 h, 5.23 mL total, 76.2 mmol). The mixture was then refluxed for 24 h. The mixture was then cooled and concentrated under vacuum to dryness to yield an oil as the crude title compound that was used directly in the next reaction.

Source