Reaction #1969513

Reaction equation

L-isopulegol

hydrogen

→

L-menthol

Conditions

Workup

1. 1
   Otherwas operated at a temperature of 85° C.
2. 2
   Otherat 75° C
3. 3
   OtherAll pipelines were provided with electrical trace
4. 4
   Temperatureheating
5. 5
   Otherthe crystallization of the enantiomerically pure L-menthol (m.p. 44° C.)

Procedure

By means of a centrifugal pump, a circulation was pumped through the main reactor at a rate of about 500 g/h at a feed of L-isopulegol of 24.5 g/h (total amount 588 g) with a purity of 99.9% by weight and 99.8% ee. The hydrogen pressure was kept constant at 40 bar. The main reactor was operated at a temperature of 85° C. and the postreactor at 75° C. All pipelines were provided with electrical trace heating to prevent the crystallization of the enantiomerically pure L-menthol (m.p. 44° C.). This gave L-menthol in an amount of 597 g, corresponding to a rate of 24.9 g/h. The L-menthol obtained in this way (99.8% ee) was analyzed by gas chromatography. The chemical purity of the L-menthol discharge is listed in Table 1.

Source