Reaction #1951044

Reaction equation

di-tert-butyl hydrogen phosphate

tetramethylammonium hydroxide

→

tetramethylammonium di-tert-butyl hydrogen phosphate

Solvents

acetone

Conditions

Workup

1. 1
   Otherthe homogeneous solution was evaporated under reduced pressure
2. 2
   Otherto provide a solid, which
3. 3
   Otherwas crystallized
4. 4
   Temperaturefrom refluxing 1,2-dimethoxyethane

Procedure

A solution of the di-tert-butyl hydrogen phosphate obtained in step a) was dissolved in acetone (10 ml) and cooled to 0° C. To this solution was added a 10% aqueous solution of tetramethylammonium hydroxide (2.4 ml, 2.6 mmol), and the homogeneous solution was evaporated under reduced pressure to provide a solid, which was crystallized from refluxing 1,2-dimethoxyethane to provide tetramethylammonium di-tert-butyl hydrogen phosphate as a white solid.

Source