Reaction #1929066

Reaction equation

compound

8,8-Difluoro-1,3-diazaspiro[4.5]decane-2,4-dione

potassium hydroxide

→

1-Amino-4,4-difluorocyclohexanecarboxylic acid

Conditions

Workup

1. 1
   Temperatureat reflux overnight
2. 2
   ConcentrationThe mixture was concentrated to about 25% of the volume and, at 0-10° C.
3. 3
   ConcentrationThe solution was concentrated
4. 4
   Otherdried

Procedure

Under nitrogen gas, 4.10 g of the compound of Example 2A were suspended in 100 ml of 30% strength aqueous potassium hydroxide solution, and the mixture was stirred at reflux overnight. The mixture was concentrated to about 25% of the volume and, at 0-10° C., adjusted to pH 5.5 using concentrated aqueous hydrogen chloride solution. The solution was concentrated and dried. The residue (4.30 g) was used directly for the esterification.

Source