Reaction #1929013

Reaction equation

triethyltrifluorovinylsilane

1-chloro-4-propylcyclohexane

4,4′-di-tert-butylbiphenyl

lithium

→

[(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane

Solvents

Water

THF

Conditions

Workup

1. 1
   workup.ADDITIONare added at 0° C
2. 2
   TemperatureThe mixture is warmed slowly
3. 3
   Extractionthe batch is extracted with MTBE
4. 4
   ExtractionThe aqueous phase is extracted with MTBE
5. 5
   Washthe combined organic phases are washed with water and saturated sodium chloride solution
6. 6
   OtherThe solution is dried
7. 7
   Concentrationconcentrated under reduced pressure
8. 8
   Filtrationis filtered off
9. 9
   ConcentrationThe filtrate is concentrated under reduced pressure
10. 10
    Otherthe residue is purified by column chromatography (SiO2, pentane)

Procedure

74.1 g (0.28 mol) of 4,4′-di-tert-butylbiphenyl are initially introduced in 1000 ml of THF in an argon atmosphere, and 1.6 g (0.23 mol) of lithium (granules) are added at 0° C. After 5 h, the blue solution is cooled to −78° C., and 40.6 g (0.25 mol) of 1-chloro-4-propylcyclohexane are added. After 30 min at this temperature, 49.6 g (0.25 mol) of triethyltrifluorovinylsilane are metered in. The mixture is warmed slowly and stirred at room temperature for 16 h. Water is added, and the batch is extracted with MTBE. The aqueous phase is extracted with MTBE, and the combined organic phases are washed with water and saturated sodium chloride solution. The solution is dried using sodium sulfate and concentrated under reduced pressure. The residue is digested with methanol, and insoluble material is filtered off. The filtrate is concentrated under reduced pressure, and the residue is purified by column chromatography (SiO2, pentane), giving [(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane as a colourless oil.

Source