Reaction #1909809

Reaction equation

3-(2,6-difluorophenyl)pyrazole

chloroacetonitrile

potassium carbonate

→

1-cyanomethyl-3-(2,6-difluorophenyl)pyrazole

Yield 47.7%

Solvents

acetonitrile

Conditions

Workup

1. 1
   Temperatureunder reflux for 5 hours
2. 2
   workup.DISTILLATIONAfter acetonitrile was distilled off under reduced pressure, ethyl acetate
3. 3
   workup.ADDITIONwas added to the residue, which
4. 4
   Washwas then washed with a small amount of water
5. 5
   DryingThe organic layer was dried over sodium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
7. 7
   OtherThe residual product was recrystallized from a mixed solvent of isopropylether and diethyl ether

Procedure

3.0 g of 3-(2,6-difluorophenyl)pyrazole was dissolved in 20 ml of acetonitrile, and 2.52 g of chloroacetonitrile and 4.61 g of potassium carbonate were added thereto at room temperature, and heated under reflux for 5 hours. After acetonitrile was distilled off under reduced pressure, ethyl acetate was added to the residue, which was then washed with a small amount of water. The organic layer was dried over sodium sulfate, and the solvent was distilled off under reduced pressure. The residual product was recrystallized from a mixed solvent of isopropylether and diethyl ether to obtain 1.74 g of 1-cyanomethyl-3-(2,6-difluorophenyl)pyrazole.

Source