Reaction #1904078

ord-0754dff38c2f445d8aadbcb31972e151

Reaction equation

Nc1ccc(Br)cc1C(O)(c1cccs1)c1cccs1
(2-amino-5-bromophenyl)(dithien-2-yl)methanol
O=C(Cl)CBr
bromoacetyl chloride
O=C(CBr)Nc1ccc(Br)cc1C(O)(c1cccs1)c1cccs1
2-Bromo-N-{4-bromo-2-[hydroxy(dithien-2-yl)methyl]phenyl}acetamide

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared from (2-amino-5-bromophenyl)(dithien-2-yl)methanol and bromoacetyl chloride using the procedure described in example 1. 1H-NMR (DMSO-d6) δ 10.22 (s, 1H), 8.42 (s, 1H), 8.05 (d, J=9.0 Hz, 1H) 7.59 (m, 3H), 7.05 (m, 2H), 6.87 (m, 2H), 6.78 (d, J=3 Hz, 1H), 3.92 (s, 2H); MS (ES) m/z 484 (M−H)−.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07598237B2uspto-grants-2009_10