Reaction #1904057

ord-a0cf59c0cb6e46628e44f8a7052ba0fd

Reaction equation

CC(=O)c1cc(Br)ccc1N
1-(2-amino-5-bromo-phenyl)-ethanone
[Li][c]1nccs1
2-thiazolyl lithium
CC(O)(c1nccs1)c1cc(Br)ccc1N
1-(2-Amino-5-bromo-phenyl)-1-thiazol-2-yl-ethanol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared from 1-(2-amino-5-bromo-phenyl)-ethanone and 2-thiazolyl lithium generally according to the procedure described in example 1. 1H-NMR (DMSO-d6) δ 7.70 (d, J=3.3 Hz, 1H), 7.64 (d, J=3.2 Hz, 1H), 7.28 (d, J=2.4 Hz, 1H), 7.10 (dd, J=8.5, 2.4 Hz, 1H), 6.92 (s, 1H), 6.55 (d, J=8.5 Hz, 1H), 5.50 (s, 2H), 1.90 (s, 3H).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07598237B2uspto-grants-2009_10